This person decided to try removing Garfield from the Garfield comic strip to see what would happen. The results are somewhat disturbing in some ways. To quote the site: "Who would have guessed that when you remove Garfield from the Garfield comic strips, the result is an even better comic about schizophrenia, bipolor disorder, and the empty desperation of modern life? Friends, meet Jon Arbuckle. Let’s laugh and learn with him on a journey deep into the tortured mind of an isolated young everyman as he fights a losing battle against lonliness in a quiet American suburb."
This reminds me of The Nietzsche Family Circus in terms of how much it changes the feel of the comic strip with a simple alteration. The Nietzsche Family Circus has generated some pretty profound ones when I've experimented with it.